Félix Martín Ferroni
Doctor en Ciencias Biológicas - Universidad Nacional del Litoral
Licenciado en Biotecnología - Universidad Nacional del Litoral
Investigador Asistente CONICET
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URLs
https://www.researchgate.net/profile/Felix_Ferroni
https://www.scopus.com/authid/detail.uri?authorId=8644815200
http://orcid.org/0000-0001-6257-6898
Bio
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DR. Felix Martín Ferroni ORCID: http://orcid.org/0000-0001-6257-6898 RESEARCHER, National Scientific and Technical Research Council (CONICET)-CCT Santa Fe Department of Physics, Biochemistry and Biological Sciences School Universidad Nacional del Litoral Ciudad Universitaria, Paraje. El Pozo C.C. Nº 242, Ruta Nacional 168, km 472, Santa Fe (S3000ZAA). e-mail: Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.; Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo. |
UNIVERSITY EDUCATION
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2005-2010 |
PhD in Biological Sciences Universidad Nacional del Litoral, Santa Fe, Argentina |
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1999-2005 |
BSc-MSc, Biotechnology Universidad Nacional del Litoral, Santa Fe, Argentina |
ACADEMIC APPOINTMENTS
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Dec2015-to date |
RESEARCHER, CONICET. Dept. Physics, Biochemistry and Biological Sciences School, Universidad Nacional del Litoral. Research: “ENZYMES WITH CUPREDOXIN-DOMAINS FROM EXTREMOPHILES AND SOIL BACTERIA. BIOCATALYSTS FOR BIOSENSING”. |
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Apr2017-to date |
Teaching Assistant (JTP). Dept. Physics, Biochemistry and Biological Sciences School, Universidad Nacional del Litoral. |
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Feb2013-Dec2015 |
NRF-RISA Free-standing Postdoctoral Fellowship- University of The Free State. Department of Microbial, Biochemical and Food Biotechnology. Natural of Agricultural Sciences Faculty, University of The Free State. Bloemfontein, South Africa. Advisor: Dr. Dirk Opperman (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Research: “Structure-function relationships of cytochrome P450s and Baeyer-Villiger monooxygenases and their use in biocatalysis”. “Cryptic fungal Baeyer-Villiger monooxygenases”. |
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Nov2012-Nov 2014 |
Teaching Assistant (JTP). Dept. Physics, Biochemistry and Biological Sciences School, Universidad Nacional del Litoral. |
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Apr2010-Nov2012 |
Postdoctoral Research Fellow-CONICET. Universidad Nacional del Litoral, Santa Fe, Argentina. Advisor: DR. Carlos D. Brondino (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Department of Physics. Research: Heterologous expression, characterization, and site-directed spin labeling of redox metalloenzymes for Continuous Wave Electronic Paramagnetic Resonance (CW-EPR) studies. Teaching Auxiliary of Physics. Department of Physics, Biochemistry and Biological Sciences School, Universidad Nacional del Litoral. |
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Apr2005- Mar2010 |
Biological Sciences PhD. Program in Biological Sciences, Universidad Nacional del Litoral, Argentina. Advisor: DR. Carlos D. Brondino (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Department of Physics. Doctoral dissertation: Molecular, kinetic and spectroscopic properties of Molybdenum-mononuclear proteins: Nitrate Reductases from Sinorhizobium meliloti 2011 and Aldehyde Oxidoreductase from Desulfovibrio gigas. |
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Nov2006 |
SECYT-GRICES GRANT, RESEARCH INTERNSHIP at the REQUIMTE-Universidad Nova de Lisboa, Portugal. Argentina-Portugal Cooperation Project (PO/PA05-EVI/002). GRICES (Portugal) and SECYT (Argentina). |
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Aug2004-Apr2005 |
Undergraduate researcher, BSc-MSc Thesis. Advisor: DR. Alberto A. Iglesias (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Molecular Enzymology Laboratory, Biochemistry and Biological Sciences School, Universidad Nacional del litoral, Argentina. Disertation: Glycogen synthesis in Gram positive bacteria: the ADP-glucose pyrophosphorylase from Streptococcus mutans. |
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Mar2002-Feb2003 |
Undergraduate researcher. Advisor: DR. Héctor C. Goicoechea (Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.). Department of Analytical Chemistry. Biochemistry and Biological Sciences School. Universidad Nacional del Litoral, Argentina. Research: Development and validation of analytical methods for drugs and metabolites determination in complex mixtures (pharmaceutical and biological samples) using spectroscopical techniques and chemometry. |
AWARDS & HONORS
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2009 |
Proteomics: Techniques and applications. The Complutense University (Summer courses). Fundación Carolina´s Fellowship. Universidad Complutense, Madrid, Spain. |
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2005 |
Best graduate qualification of BSc-MSc Biotechnology. (9.3/10). Biochemistry and Biological Sciences Shool, Universidad Nacional del Litoral, Santa Fe, Argentina. |
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2003 |
International Student Scholarship. Universidad Autónoma de Madrid. Sciences School. Universidad Autónoma de Madrid. Madrid, Spain. |
PUBLICATIONS (11); (104 citations; h-index: 6)
Opperman D.J., Murgida D.H., Dalosto S.D., Brondino C.D., Ferroni F.M. (2019). A three-domain copper-nitrite reductase with a unique sensing loop. IUCrJ 6: 248-258.
Cristaldi J.C., Gómez M.C., González P.J., Ferroni F.M., Dalosto S.D., Rizzi A.C., Rivas M.G., Brondino C.D. (2018). Study of the Cys-His bridge electron transfer pathway in a copper-containing nitrite reductase by site-directed mutagenesis, spectroscopic, and computational methods. Biochim Biophys Acta. 1862:752-760.
Ferroni F.M., Tolmie C., Smit M.S., Opperman D.J. (2017). INSIDE COVER: Alkyl formate ester synthesis by a fungal Baeyer-Villiger monooxygenase. Chembiochem 18: 485.
Ferroni F.M., Tolmie C., Smit M.S., Opperman D.J. (2017). Alkyl formate ester synthesis by a fungal Baeyer-Villiger monooxygenase. Chembiochem 18: 515-517.
Ferroni, F.M., Tolmie, C., Smit, M., Opperman, D.J. (2016) Structural and catalytic characterization of a fungal Baeyer-Villiger monooxygenase. PLoS One 11: e0160186
Ferroni, F.M., Smit, M., Opperman, D.J. (2014) Functional divergence between closely related Baeyer-Villiger monooxygenases from Aspergillus flavus. J. Mol. Catal. B: Enzymatic. 107: 47-54.
Ferroni, F.M., Marangon, J., Neuman, N.I., Cristaldi, J.C., Brambilla, S.M., Guerrero, S.A., Rivas, M.G., Rizzi, A.C., Brondino, C.D. (2014) Pseudoazurin from Sinorhizobium meliloti as an electron donor to copper-containing nitrite reductase: influence of the redox partner on the reduction potentials of the enzyme copper centers. J. Biol. Inorg. Chem. 19: 913-921.
Neuman,N.I., Franco, V.G., Ferroni,F.M., Baggio, R., Passeggi, M.C.G., Rizzi, A.C., Brondino, C.D. (2012) Single Crystal EPR of the mixed-Ligand complex of copper(II) with L-glutamic acid and 1,10-phenanthroline: a study on the narrowing of the hyperfine structure by exchange. J. Phys. Chem. 116: 12314-12320.
Ferroni, F.M., Guerrero, S.A., Rizzi, A.C., Brondino, C.D. (2012) Overexpression, purification and biochemical and spectroscopic characterization of copper-containing nitrite reductase from Sinorhizobium meliloti 2011. Study of the interaction of the catalytic copper center with nitrite and NO. J. Inorg. Biochem. 114: 8-14.
Ferroni, F.M., Rivas, M.G., Rizzi, A.C., Lucca, M.E., Perotti, N.I., Brondino, C.D. (2011) Nitrate reduction associated with respiration in Sinorhizobium meliloti 2011 is performed by a membrane-bound molybdoenzyme. Biometals, 24: 891-902.
Santos-Silva, T., Ferroni, F.M., Thapper, A., Marangon, J., González, P., Rizzi, A.C., Moura, I., Moura, J.J.G., Romão, M.J. and Brondino, C.D. (2009) Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system. J. Am. Chem. Soc. 131: 7990-7998.
Cámara, M.S., Ferroni, F.M., De Zan, M. and Goicoechea, H.C. (2003). Sustained modelling ability of artificial neural networks in the analysis of two pharmaceuticals (dextropropoxyphene and dipyrone) present in unequal concentrations. Anal. Bioanal. Chem. 376: 838-843.
MEETINGS AND SCIENTIFIC REUNIONS (last 7):
2017- Joint Meeting Of Bioscience Societies. LIII Annual Meeting Of Argentine Society Of Biochemistry and Molecular Biology (SAIB). “HOW DEEP IS YOUR BLUE? A NOVEL COPPER CONTAINING NITRITE REDUCTASE FROM A THERMOPHILIC BACTERIUM ISOLATED FROM THE SOUTH AFRICAN DEEP SURFACE”. Ferroni F.M., Schmidt, F.B., Brondino, C.D, Opperman, D.J. Buenos Aires, Argentina.
2016- CATSA 2016 conference. “Alkyl formate ester synthesis by a fungal Baeyer-Villiger monooxygenase”. Tolmie, C., Ferroni, F.M., Smit, M. and Opperman, D.J. November, Central Drakensberg, South Africa.
2015- BIOTRANS 2015. “Structural insights into the substrate specificity of Baeyer-Villiger monooxygenases”. Ferroni, F.M., Smit, M. and Opperman, D.J. July. Vienna, Austria.
2015- BIOTRANS 2015. “Expanding the biocatalytic toolbox with Baeyer-Villiger monooxygenases from Aspergillus Flavus”. Tolmie, C., Ferroni, F.M., Smit, M. and Opperman, D.J. July. Vienna, Austria.
2014- South African Society of Biochemistry and Molecular Biology. “Baeyer-Villiger monooxygenases from Aspergillus flavus NRRL3357. Characterization of four novel Baeyer-Villiger monooxygenases”. Ferroni, F.M., Smit, M. and Opperman, D.J. 6-9 July. Rawsonville, South Africa.
2013- 24th Annual Conference Catalysis Society of South Africa. “Regio- and enantiodivergent oxidations performed with cryptic Baeyer-Villiger monooxygenases from Aspergillus flavus”. Ferroni, F.M., Smit, M. and Opperman, D.J. 17-20 November. Port Edward, South Africa.
2013- BIOTRANS 2013. “Exploring cryptic Baeyer-Villiger monooxygenases from fungi”. Ferroni, F.M., Tolmie, C., Smit, M. and Opperman, D.J. July. Manchester, United Kingdom.
KNOWLEDGE INNOVATION / TRANSFERENCE / PATENTS
TRANSFERENCE AGREEMENT. NATIONAL SCIENTIFIC AND TECHNICAL RESEARCH COUNCIL (CONICET-Argentina) - GENE OASIS PTE LTD (Reg. No. 200106047G, Singapore). Memorandum of understanding for the knowledge transference and technical advice for the production of rSmNirK (Copper nitrite reductase derived from Sinorhizobium meliloti 2011). Dr. Felix M. Ferroni, Dr. Carlos Dante Brondino and Dr. Alberto Rizzi representing Department of Physics - FBCB-UNL/CONICET. Kah Meng Lim (CEO) acting in place of or on behalf of GENE OASIS PTE LTD.
HUMAN RESOURCE TRAINING
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2012 |
Mr. Mariano Pasquetto´s advisor, BSc-MSc Biotechnology Student. Dept. Physics, Biochemistry and Biological Sciences. Universidad Nacional del Litoral. Santa Fe, Argentina. Disertation: Study of metalloproteins that are involved in nitrogen cycle in Rhizobiales bacterium order. Disertation: 9/10 |
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2013 |
Ms. Silvina Brambilla´s advisor, BSc-MSc Biotechnology Student. Dept. Physics, Biochemistry and Biological Sciences. Universidad Nacional del Litoral. Santa Fe, Argentina. Disertation: Study of metalloproteins that are involved in nitrogen cycle in Rhizobiales bacterium order: study of a pseudoazurin from Sinorhizobium meliloti 2011. Disertation: 10/10. |
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2017 |
Ms. Cintia Ramirez´s advisor, BSc-MSc Biotechnology Student. Dept. Physics, Biochemistry and Biological Sciences. Universidad Nacional del Litoral. Santa Fe, Argentina. Disertation: Study of metalloproteins involved in the nitrogen cycle in Rhizobiales: optimization of the expression of the physiological mediators of copper-nitrite reductases. |
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2019 |
Ms. Florencia Schmidt´s advisor, BSc-MSc Biotechnology Student. Dept. Physics, Biochemistry and Biological Sciences. Universidad Nacional del Litoral. Santa Fe, Argentina. Disertation: Denitrification in extremophiles: truncated forms and variants of a three-domain copper-nitrite reductase from Thermus scotoductus SA-01. (CIENTIBECA) |
Gómez María Cecilia
Licenciada en Bioinformática
Estudiante de doctorado en Ciencias Biológicas
Ayudante de Primera
CV
BIO
Egresada en el año 2012 de la carrera Licenciatura en Bioinformática, dictada en la Facultad de Ingeniería perteneciente a la Universidad Nacional de Entre Ríos.
Se incorporó a la Universidad Nacional del Litoral como pasante de investigación en el Departamento de Física de la Facultad de Bioquímica y Ciencias Biológicas durante el 2012, realizando actividades de laboratorio y computacionales sobre proteínas de Cobre.
Participó de un programa de pasantía de verano organizado por el IFSC en San Carlos durante los meses de febrero y marzo de 2013. El tema de trabajo fue la adquisición de imágenes de cortes de hojas de plantas y clasificación de las mismas por medio de patrones bajo la dirección del Dr. Odemir Martínez Bruno en el grupo de Computación Cientifica.
Desde abril del 2013 comenzó su tesis de Doctorado en Ciencias Biologicas titulada "Mecanismo de reacción de la enzima de cobre nitrito reductasa estudiado por mutagénesis sitio-dirigida y marcado con sondas de espín (SDSL) y modelado molecular" en el grupo de investigación Metaloproteínas y Sistemas Modelo bajo la dirección del Dr. Carlos Brondino y la co-dirección del Dr. Sergio Dalosto. Posee una beca de CONICET tipo 1.
Además tiene funciones docentes en las asignaturas Física I y Física II de las carreras Licenciatura en Biotecnología y Bioquímica de la Facultad de Bioquímica y Ciencias Biológicas.
Passeggi Mario
FOTO
(titulo postrado)
(titulo grado)
(cargo en el departamento)
E-mail:
CV
BIO
Alberto Rizzi
FOTO
Bioquímico // BS degree in Biochemistry
Doctor en Ciencias Biológicas // Ph.D. in Biological Sciences
Prof. Adjunto dedicación exclusiva
E-mail:Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.
En 1983 me gradué como Bioquímico en la Universidad Nacional del Litoral. En 2003 recibí el título de Doctor en Ciencas Biológicas en la misma Universidad y posteriormente realicé una etapa postdoctoral en el Instituto Max-Planck de Química Bioinorgánica, Alemania. Actualmente soy Profesor del Departamento de Física de la FBCB. Mi area de investigación comprende química bioinorgánica, fisicoquímica del estado sólido, magnetoquímica de moléculas biológicas, y biofisicoquímica. Los trabajos están focalizados en estudiar sistemas bioinorgánicos simples como modelo de compuestos biológicos mas complejos, utilizando fundamentalmente Resonancia Paramagnética Electrónica y mediciones de propiedades magnéticas como susceptibilidad magnética, magnetización, y calor específico a bajas temperaturas. Actualmente estoy trabajando en problemas de estructura electrónica e interacciones magnéticas de iones de metales de transición (Cu(II), Co(II), lantánidos(III)) en metaloproteínas y en compuestos modelo de esas biomoléculas.
Alberto C. Rizzi received B.S. (Biochemist, 1983) and Ph.D. (2003) degrees from Universidad Nacional del Litoral, Argentina and was a postdoctoral fellow at Max Planck Institute for Bioinorganic Chemistry (Germany). He is now professor in the Department of Physics in the Facultad de Bioquímica y Ciencias Biológicas at Universidad Nacional del Litoral. His research interests include the role of transition metals ions in biology and the study of bioinorganic systems as models for complex biological compounds using Electron Paramagnetic Resonance (EPR) and magnetic measurements.
Publicaciones representativas // Some selected publications
One Electron Reduced Square Planar Bis(benzene-1,2-dithiolato) Copper Dianionic Complex and Redox Switch by O2/HO− Biplab K. Maiti, Luisa B. Maia, Kuntal Pal, Bholanath Pakhira, Teresa Avilés, Isabel Moura, Sofia R. Pauleta, José L. Nuñez, Alberto C. Rizzi, Carlos D. Brondino, Sabyasachi Sarkar, José J. G. Moura, Inorganic Chemistry, 2014, 53, 12799-12808.
Isotropic exchange interaction between Mo and the proximal FeS center in the xanthine oxidase family member aldehyde oxidoreductase from Desulfovibrio gigas on native and polyalcohol inhibited samples: an EPR and QM/MM study María C. Gómez · Nicolás I. Neuman · Sergio D. Dalosto · Pablo J. González · José J. G. Moura · Alberto C. Rizzi · Carlos D. Brondino, Journal of Biological Inorganic Chemistry, 2015, 20, 233-242.
Transition from isolated to interacting copper(II) pairs in extended lattices evaluated by single crystal EPR spectroscopy Nicolás I. Neuman, Emerson Burna, Ricardo Baggio, Mario C. G. Passeggi, Alberto C. Rizzi, Carlos D. Brondino Inorganic Chemistry Frontiers, 2015, 2, 837-845.
Ligand Binding to Chlorite Dismutase from Magnetospirillum sp Amy De Schutter, Hugo D. Correia, Diana M. Freire, María G. Rivas, Alberto Rizzi, Teresa Santos-Silva, Pablo J. Gonzalez, Sabine Van Doorslaer Journal of Physical Chemistry B, 2015, aceptado.